Synthetic Approaches of Pyrazolyl Quinolines

This review article represents a survey of the synthetic strategies leading to pyrazolyl quinolines. The synthetic methods are divided into two main groups based on the type of starting reagents: 1) From quinoline ring onto a pyrazole scaffold, 2) From pyrazole ring onto a quinoline scaffold. Also, some medical applications of pyrazolyl quinoline derivatives are mentioned such as anticancer, cell proliferative disorder, glucose transport inhibitors, anti-inflammatory, and inhibitors of leukotriene production for the treatment of cardiovascular. The main purpose of this review is to present a survey of the literature on the synthetic approaches of pyrazolyl quinolines and provide useful and up-to-date data for organic and medicinal chemist since such compound has not been previously reviewed.