Fluorine Containing Molecules for Peptidomimicry: A Chemical Act to Modulate Enzymatic Activity

Fluorine atom has been used extensively to modulate the properties of various peptide-like compounds to modulate enzyme activities such as proteases. Fluorinated functionalities such as trifluoromethyl group, difluoromethyl group, fluoromethyl moiety and recently -CHF-S- were investigated. This article discusses important fluorine containing peptidomimetics, synthetic strategies, and the modulation of enzymic activities.