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2000
Volume 22, Issue 5
  • ISSN: 1570-193X
  • E-ISSN: 1875-6298

Abstract

Transition metal-free annulation/cascade reactions have been embraced as a powerful synthetic tool to access carbo/heterocyclic molecules. Among them, benzyne chemistry gained significant interest due to the formation of diverse functionalized arenes unusual carbon-carbon (C-C) or carbon-heteroatom (C-O, C-N, C-S) bond-formation under different reaction conditions. In this review, few dynamic methods have been documented to construct the synthetically and pharmaceutically valuable indazole scaffolds using benzyne precursor and various other coupling partners. In this mini-review, we have described the recent progress on metal-free cascade strategies, highlighting the contribution from several synthetic chemists, including our research work. Specific attention has been paid to offer the detailed mechanistic pathway to explain the developed methodologies.

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2025-09-13

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/content/journals/mroc/10.2174/0118756298321262240719103850
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Synthesis of Indazole Scaffolds from Arynes and Suitable Coupling Partners - A Brief Review
Mini-Reviews in Organic Chemistry 22, 463 (2025); https://doi.org/10.2174/0118756298321262240719103850
/content/journals/mroc/10.2174/0118756298321262240719103850
/content/journals/mroc/10.2174/0118756298321262240719103850
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  • Article Type:     Review Article
Keyword(s): 1H-indazoles; 2H-indazoles; annulation reactions; aryne chemistry; benzyne; N-hetero cyclic compounds

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