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2000
Volume 22, Issue 3
  • ISSN: 1570-193X
  • E-ISSN: 1875-6298

Abstract

Free radical reactions occupy an important position in synthetic organic chemistry as well as medicinal chemistry, significantly complementing and extending the synthesis of coumarin or quinolin-2-one compounds. Moreover, the use of constructing coumarin or quinolin-2-one compounds functionalized at the C3 position has certain advantages over traditional noble metal-catalyzed or high-temperature cyclization, which is more in line with the advocates of green chemistry. The design of alkenes or alkynes as radical acceptors for cascade reactions presents a novel and robust approach to obtaining coumarin or quinolin-2-one molecules. These radical cascade cyclization reactions have been well explored and studied over the past decade. As a result, we have compiled a mini-review of the rapidly developing cutting-edge research in this field, featuring typical examples and in-depth exploration of the underlying mechanisms.

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2024-01-04
2025-12-05

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Recent Advances in the Construction of Coumarin or Quinolin-2-ones Compounds via Radical Cascade Reactions
Mini-Reviews in Organic Chemistry 22, 249 (2025); https://doi.org/10.2174/0118756298278048231205053801
/content/journals/mroc/10.2174/0118756298278048231205053801
/content/journals/mroc/10.2174/0118756298278048231205053801
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  • Article Type:     Review Article
Keyword(s): alkene; alkyne; coumarin; Cyclization; electrooxidation; quinolin-2-one; radical cascade reaction

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