Letters in Organic Chemistry - Volume 20, Issue 2, 2023

Ab initio molecular orbital hybrid density functional theory (B3LYP/6-311++G**) based methods and natural bond orbital (NBO) interpretation were used to investigate the 1, 4-eliminations and the correlations between the global hardness, global electronegativity, anomeric effect, thermodynamic parameters of 3-chloro-8-methyl-8-azabicyclo[3.2.1]octane (1), 3-chloro-8-methyl-8-phosphabicyclo- [3.2.1]octane (2) a Read More

Background: The nonlinear optical properties of ferrocene-containing metalloporphyrins toward pico-second laser were studied using calculational and experimental methods, and the relationship between their structures and nonlinear absorption properties were discussed. Aims: The metal ions introduced into the porphyrin rings intensively affect the nonlinear optical properties. Methods: The nonlinear optical properties and the Read More

Scopolamine, as an anticholinergic agent, plays a regulatory role in the peripheral nervous system. In this paper, 6,7-dehydrotropinone, which is the key intermediate of scopolamine, is synthesized in moderate yield through [4+3] cyclization reaction and Barton deoxygenation reaction. This route has good application prospects with mild reaction conditions, moderate yield, and simple operating procedures.

Background: Hydrazides and hydrazones are found in a variety of bioactive compounds that have a wide range of pharmacological applications. There have been significant advancements in this field in recent years, with many new aspects of hydrazone chemistry and applications emerging. Methods: This piqued researchers' interest in synthesizing a variety of hydrazone derivatives for various biological applications. Results: Read More

Background: A novel metal-free approach is reported for the synthesis of 5Hchromeno[ 4,3-b]pyridine derivatives. Indeed, chromene derivatives are found to exhibit a broad spectrum of biological activities such as antibacterial, antirhinovirus, antioxidant, cytotoxic, anticancer, and antimicrobial properties. Methods: This method provides easy access to a large number of 5H-chromeno[4,3-b]pyridine scaffolds by the Read More

The present work reports the hydrothermal synthesis of Fe doped gallium oxide nanoparticles and its characterization by IR, XRD, SEM, and EDX techniques. The characterization of Fe doped gallium oxide nanomaterial reveals the 18.58 nm particle size with monoclinic phase. The catalytic activity of nanomaterial was efficiently assessed for one-pot domino Knoevenagel and Michael's addition of different aldehydes, dimedo Read More

The Ru exchanged MMT clay was synthesized with different Ru metal stacking using the wet impregnation method. All the developed materials were analyzed with advanced analytical techniques. All the data were found in good agreement with each other. Furthermore, all the catalysts were tested for the reduction of aromatic and aliphatic nitro compounds to the corresponding amines in conventional and ionic liquid reaction Read More

The efficient, straightforward, and green procedure was established in the direction of synthesis of 4-arylmethylene-3-methylisoxazol-5(4H)-one derivatives using the malic acid, which acted as the catalyst for the three-component heterocyclization reaction. In this reaction, aryl/heteroaryl aldehydes, hydroxylamine hydrochloride, and ethyl acetoacetate/ethyl benzoylacetate were applied as the reactants. The reaction was Read More

Aims: The aim of the study was to extract and characterize alginate from a new source, conduct synthesis and characterization of novel aminated alginate derivatives, make a comparison of physicochemical properties of extracted sodium alginate with its aminated derivatives, and investigate the effect of diamines chain length on physicochemical properties of newly synthesized derivatives. Background: Alginate is a natural bio Read More

Background: A stereoselective synthetic strategy toward (+)-paecilomycin F is reported. The approach utilizes readily available commercial 2,4,6-trihydroxy benzoic acid and easily accessible chiral R(+)-propylene oxide as starting materials. Methods: The synthesis involves regioselective Grignard reaction, Wittig reaction, Sharpless asymmetric dihydroxylation, Barbier-type allylation, Stille-coupling and ring-closing metathe Read More