Synthesis and Electrochemical Behavior of Some Dendritic Polyphenols as Antioxidants

Eight dendritic polyphenols (generation1) of hydroxy benzoic and hydroxy cinnamic acids were synthesized in good overall yields using Mitsunobu reaction and BOP coupling agent and their antioxidant activities including radical scavenging activity were studied by cyclic voltammetry. Antioxidants with strong free radical scavenging abilities and devoid of prooxidant effects would be of immense biological importance. Therefore to minimize prooxidant effects and to increase free radical quenching properties, the dendrimers were designed with metal chelating compounds as core and with a periphery, rich in phenolic hydroxyl groups, benzylic hydrogens and electron donating ring substituents.