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- ISSN: 1570-1786
- E-ISSN: 1875-6255
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Synthesis of Key Fragments of 19-Membered Cytotoxic Macrolide Amphidinolide E
- Source: Letters in Organic Chemistry, Volume 10, Issue 1, Jan 2013, p. 65 - 69
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- 01 Jan 2013
Abstract
Amphidinolide E is a 19-membered macrolide possessing potent cytoxic activity. The macrolide core having two key intermediates alcohol and acid was synthesized efficiently. The THF ring segment was synthesized from Dglucose as chiral precursor, whereas the cis-tetrahydrofuran ring was established by stereoselective intramolecular oxymercuration reaction. The acid component having E-diene was established by Stille cross coupling of vinyl iodo and vinly stannane segment. Coupling reaction of acid segment and alcohol was examined.
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