One-Pot, Solvent Free Synthesis of Hantzsch 1, 4-Dihydropyridines Using β-Cyclodextrin as a Supramolecular Catalyst

A novel, solvent free and efficient one pot synthesis of 1, 4-dihydropyridine derivatives was achieved in good yields via three component reaction of aldehydes, ethyl acetoacetate and ammonium acetate using inexpensive β- cyclodextrin as a supramolecular catalyst. The catalyst can be recovered and reused without loss of activity.