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2000
Volume 7, Issue 8
  • ISSN: 1570-1786
  • E-ISSN: 1875-6255

Abstract

An efficient, metal-free and chemo-selective Friedel-Crafts allylation of indoles in 2,2,2-trifluoroethanol (TFE) is developed. A possible mechanism has also been discussed to explain the observed competitive pathways in this reaction system.

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/content/journals/loc/10.2174/157017810793811696
2010-12-01
2025-09-19

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  • Article Type:     Research Article
Keyword(s): 2,2,2-trifluoroethanol; alkylation; allyl acetate; aromatic compounds; benzyl alcohols; C-3 alkylation; catalyst; chemoselectivity; dimethylindole; Friedel-Crafts alkylation; hydrogen bond activation; indole; indole substrates; Lewis acid; nucleophilic; petroleum ether; reactivity; regioselectively; solubility; solvent; solvolysis; transformation; Trifluoroethanol

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