Full text loading...
- ISSN: 1570-1786
- E-ISSN: 1875-6255
-
Guanylation of Amines with Isonitriles in the Presence of Iodine
- Source: Letters in Organic Chemistry, Volume 7, Issue 7, Oct 2010, p. 566 - 570
-
- 01 Oct 2010
Abstract
A novel one-pot protocol for the synthesis of substituted guanidines was developed. The reaction involved guanylation of amines with isonitriles in the presence of iodine and sodium bicarbonate. This procedure can be applied to the preparation of various substituted guanidines in moderate to good yields.
© Bentham Science Publishers