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- ISSN: 1570-1786
- E-ISSN: 1875-6255
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One-Pot Four-Component Synthesis of 3-(1,3,4-Thiadiazol-2-ylamino)-3-arylpropanoates
- Source: Letters in Organic Chemistry, Volume 7, Issue 6, Sep 2010, p. 467 - 471
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- 01 Sep 2010
Abstract
A novel one-pot four-component synthetic method for 3-(1,3,4-thiadiazol-2-ylamino)-3-arylpropanoates by condensation of 2-amino-1,3,4-thiadiazoles, aldehydes, Meldrum's acid and aliphatic alcohols catalyzed by p-toluenesulfonic acid was described. The protocol has advantages of mild conditions, high yield and simple work-up procedure.
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