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- ISSN: 1570-1786
- E-ISSN: 1875-6255
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Direct Experimental Evidence for the Priority of Flexible Ligand Skeleton in Asymmetric Friedel-Crafts Alkylation of Indole with Nitroalkenes
- Source: Letters in Organic Chemistry, Volume 7, Issue 2, Mar 2010, p. 114 - 120
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- 01 Mar 2010
Abstract
Direct experimental evidence for the priority of flexible ligand skeleton in asymmetric Friedel-Crafts alkylation was obtained through XRD analysis of flexible ligand/ZnCl2 complex, as well as synthesis of dihydroacridine-linked bis(oxazoline) ligands with planar rigid scaffold. A transition state model without NH…π interaction was proposed for the rigid ligands to interpret the inversion of absolute configuration.
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