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- ISSN: 1570-1786
- E-ISSN: 1875-6255
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Benzoxazine and Benzodioxine as Indole Isosteres in Indolocarbazoles Series: Synthesis and Biological Evaluation
- Source: Letters in Organic Chemistry, Volume 7, Issue 2, Mar 2010, p. 121 - 126
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- 01 Mar 2010
Abstract
New series of structure based on original benzodioxine and benzoxazine heterocycles were prepared leading to potential anticancer lead compounds. In this paper, we described a convenient approach via a Diels-Alder cycloaddition in order to efficiently provide three new indole isosteres in indolocarbazoles series. Their first cytotoxic evaluation was also reported.
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