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- ISSN: 1570-1786
- E-ISSN: 1875-6255
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Bismuth Nitrate Promoted Fischer Indole Synthesis: A Simple and Convenient Approach for the Synthesis of Alkyl Indoles
- Source: Letters in Organic Chemistry, Volume 6, Issue 2, Mar 2009, p. 159 - 164
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- 01 Mar 2009
Abstract
A novel one-pot fisher indole synthesis approach has been developed by using bismuth nitrate as a catalyst. Yields around 90-95% were obtained after reaction in methanol at reflux temperature in 20-40 min. Apart from the mild reaction conditions of the process and its excellent results, the simplicity of product isolation and the possibility to recycle the bismuth nitrate offers a significant advantage.
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