One-pot Synthesis of 2-Substituted Imidazo[2,1-b][1,3]benzothiazoles via Coupling-Cyclization Under Pd-Cu Catalysis in Water

The reaction of 2-imino-3-(2-propynyl)-1,3-benzothiazole with various aryl iodides, catalyzed by Pd-Cu, in the presence of sodium lauryl sulfate as the surfactant and potassium carbonate as the base, in water, leads to the formation of 2-substituted imidazo[2,1-b][1,3]benzothiazoles.