Novel Microwave-Assisted One-Pot Synthesis of Heterocycle Phosphor Esters and Cyclic Oxophospholes with Antibiotic Activity

Reactions of 5,6-di-(2`-furyl)-3-oxo-2,3-dihydropyridazin-4-carbonitrile (1) with Wittig-Horner reagents were investigated under microwave irradiation, and the effect of basic catalysis. The methodology afforded moderate to high yields of fused heterocycles bearing a phosphonate ester and / or phosphor-containing fused heterocycles. Bioassay results showed that the antibiotic activity of the new synthesized phosphorus compounds is significantly high when compared to available Streptomycin and Mycostatin (standard).