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- ISSN: 1570-1786
- E-ISSN: 1875-6255
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High-Yielding Aminocarbonylation of 3-Iodo-2-Tropene by Using Amino Acid Esters as N-Nucleophiles
- Source: Letters in Organic Chemistry, Volume 4, Issue 4, Jun 2007, p. 236 - 238
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- 01 Jun 2007
Abstract
3-Iodo-2-tropene, synthesised from the corresponding ketone (tropinone) via its hydrazone, was carbonylated in palladium-catalysed homogeneous aminocarbonylation reactions. The 3-carboxamides containing both the tropene and the aminoacid moieties of biological importance were obtained in chemospecific reactions and isolated in up to 85 % yields.
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