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- ISSN: 1570-1786
- E-ISSN: 1875-6255
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New Synthesis of 3-Aryl Isoquinolines by Pd-Catalyzed Suzuki Cross-Coupling
- Source: Letters in Organic Chemistry, Volume 4, Issue 2, Mar 2007, p. 86 - 91
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- 01 Mar 2007
Abstract
A new synthetic approach to 3-aryl isoquinolines, based on the Pd-catalyzed Suzuki cross-coupling reaction, is reported. The described procedure represents an efficient method to prepare 3-aryl isoquinolines by reaction of a preformed 3-chloro isoquinoline with a phenylboronic acid, especially when the nitrogen atom is positively charged.
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