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- ISSN: 1570-1786
- E-ISSN: 1875-6255
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Synthesis of Pyrimidine-Annulated Heterocycles: Facile Sulfoxide Rearrangement of 1, 3-Dimethyl-5-(Aryloxybut-2-Ynylthio) Pyrimidine-2, 4-Dione (SUPPORTING DATA)
- Source: Letters in Organic Chemistry, Volume 4, Issue 2, Mar 2007, p. 134 - 136
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- 01 Mar 2007
Abstract
A number of thieno [3,2-b] pyrimidines are regioselectively synthesized in good yields from 5-(4- aryloxybut-2-ynylthio) via sulfoxide rearrangement/tandem cyclization protocol by the treatment of the sulfides with one equivalent of m-CPBA in chloroform at 0-5°C with stirring the reaction mixture at room temperature for 2 h.
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