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- ISSN: 1570-1786
- E-ISSN: 1875-6255
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Crotylation of (R)-2,3-Cyclohexylideneglyceraldehyde: A Simple Strategy for the Synthesis of Enantiopure anti-Alzheimer (R)-Arundic Acid
- Source: Letters in Organic Chemistry, Volume 3, Issue 12, Dec 2006, p. 922 - 925
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- 01 Dec 2006
Abstract
(R)-Arundic acid 15 was prepared in a simple manner and with absolute optical purity via Cu and Fe mediated and Luche's crotylation of 1 with bromides 6a,b. Co wasn't a good mediator for these crotylation reactions. The stereoselectivity for all crotylations were similar producing mainly 7b, c, besides a small amount of 7a.
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