Novel One-Pot Synthesis of Amide Derivatives of Methylenebisphosphonate Utilizing the Mesyl Moiety as Leaving Group

Jonna Jokiniemi; Markku Ahlgren; Jouko J. Vepsalainen

doi:10.2174/157017806779467951

ISSN: 1570-1786
E-ISSN: 1875-6255

Novel One-Pot Synthesis of Amide Derivatives of Methylenebisphosphonate Utilizing the Mesyl Moiety as Leaving Group
Authors: Jonna Jokiniemi¹, Markku Ahlgren² and Jouko J. Vepsalainen³
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¹ University of Joensuu, Department of Chemistry, P.O. Box 111, FIN-80101 Joensuu, Finland. ² University of Joensuu, Department of Chemistry, P.O. Box 111, FIN-80101 Joensuu, Finland. ³ University of Joensuu, Department of Chemistry, P.O. Box 111, FIN-80101 Joensuu, Finland.
Source: Letters in Organic Chemistry, Volume 3, Issue 12, Dec 2006, p. 898 - 900
DOI: https://doi.org/10.2174/157017806779467951
- Available online: 01 Dec 2006

Abstract

A novel one-pot synthesis was developed for the preparation of partial amide esters of (dichloromethylene)bisphosphonic acid from readily available tetramethyl ester with good selectivity and purity.

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2006-12-01

2025-09-03

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Article Type: Research Article

Keyword(s): amide esters; amination; Bisphosphonate; mesyl leaving group; selective synthesis

Novel One-Pot Synthesis of Amide Derivatives of Methylenebisphosphonate Utilizing the Mesyl Moiety as Leaving Group

Abstract

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