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- ISSN: 1570-1786
- E-ISSN: 1875-6255
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A Practical Synthesis of Thio-Bisphosphonic Acids For the Treatment of Arthritis, Based on the Chemistry of Tetraethyl Methylene-1,1- Bisphosphonate
- Source: Letters in Organic Chemistry, Volume 3, Issue 8, Aug 2006, p. 634 - 639
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- 01 Aug 2006
Abstract
The synthesis of novel S-bisphosphonates (S-BPs) by two different approaches is described. Hydrolysis of the resulted BPs with conc. HCl afforded the corresponding thio-bisphosphonic acids. The properties of these compounds in the rat adjuvant model of arthritis, and the synthetic routes to these and related compounds are detailed.
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