Chiral Amino-Amides as Solution Phase and Immobilized Ligands for the Catalytic Asymmetric Alkylation of Aromatic Aldehydes

Giordano Lesma; Bruno Danieli; Daniele Passarella; Alessandro Sacchetti; Alessandra Silvani

doi:10.2174/157017806777828529

ISSN: 1570-1786
E-ISSN: 1875-6255

Chiral Amino-Amides as Solution Phase and Immobilized Ligands for the Catalytic Asymmetric Alkylation of Aromatic Aldehydes
Authors: Giordano Lesma¹, Bruno Danieli², Daniele Passarella³, Alessandro Sacchetti⁴ and Alessandra Silvani⁵
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¹ Dipartimento di Chimica Organica e Industriale, via Venezian 21, 20133 Milano, Italy. ² Dipartimento di Chimica Organica e Industriale, via Venezian 21, 20133 Milano, Italy. ³ Dipartimento di Chimica Organica e Industriale, via Venezian 21, 20133 Milano, Italy. ⁴ Dipartimento di Chimica Organica e Industriale, via Venezian 21, 20133 Milano, Italy. ⁵ Dipartimento di Chimica Organica e Industriale, via Venezian 21, 20133 Milano, Italy.
Source: Letters in Organic Chemistry, Volume 3, Issue 6, Jun 2006, p. 430 - 436
DOI: https://doi.org/10.2174/157017806777828529
- Available online: 01 Jun 2006

Abstract

Novel chiral amino-amide 9-keto-bispidines are investigated as ligands in the addition reaction of diethylzinc to aromatic aldehydes. The ligands are easily obtained by a single step procedure starting from commercially available products. Selected ligands were also supported onto different insoluble resins in order to test their activity as heterogeneous catalysts.

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2006-06-01

2025-10-13

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Article Type: Research Article

Keyword(s): 3,7-diazabicyclo[3.3.1]nonane; asymmetric synthesis; bispidine; Chiral ligand; diethylzinc

Chiral Amino-Amides as Solution Phase and Immobilized Ligands for the Catalytic Asymmetric Alkylation of Aromatic Aldehydes

Abstract

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