A Simple Synthesis of Orthogonally Protected 2,5-Diaminocyclohexanecarboxylic Acids

Lorand Kiss; Istvan Szatmari; Ferenc Fulop

doi:10.2174/157017806777828501

ISSN: 1570-1786
E-ISSN: 1875-6255

A Simple Synthesis of Orthogonally Protected 2,5-Diaminocyclohexanecarboxylic Acids
Authors: Lorand Kiss¹, Istvan Szatmari² and Ferenc Fulop³
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¹ Institute of Pharmaceutical Chemistry, University of Szeged, H-6701 Szeged, POB 427, Hungary. ² Institute of Pharmaceutical Chemistry, University of Szeged, H-6701 Szeged, POB 427, Hungary. ³ Institute of Pharmaceutical Chemistry, University of Szeged, H-6701 Szeged, POB 427, Hungary.
Source: Letters in Organic Chemistry, Volume 3, Issue 6, Jun 2006, p. 463 - 467
DOI: https://doi.org/10.2174/157017806777828501
- Available online: 01 Jun 2006

Abstract

Simple and efficient methods have been developed for the synthesis of orthogonally protected 2,5- diaminocyclohexanecarboxylic acid diastereomers via the stereocontrolled transformation of 2-benzyloxycarbonylamino-4-cyclohexenecarboxylic acid to its iodolactone or epoxide.

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2006-06-01

2025-10-12

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Article Type: Research Article

Keyword(s): Diaminocarboxylic acids; orthogonal protection; β-amino acids; β-peptides

A Simple Synthesis of Orthogonally Protected 2,5-Diaminocyclohexanecarboxylic Acids

Abstract

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