Reduction of N-Methoxy-N-Methylamides to the Corresponding Amines with AlCl3/LiAlH4

Maria Luisa Di Gioia; Antonella Leggio; Adolfo Le Pera; Angelo Liguori; Francesca Perri; Maria Caterina Viscomi

doi:10.2174/157017806777828466

ISSN: 1570-1786
E-ISSN: 1875-6255

Reduction of N-Methoxy-N-Methylamides to the Corresponding Amines with AlCl3/LiAlH4
Authors: Maria Luisa Di Gioia¹, Antonella Leggio², Adolfo Le Pera³, Angelo Liguori⁴, Francesca Perri⁵ and Maria Caterina Viscomi⁶
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¹ Dipartimento di Scienze Farmaceutiche, Via P. Bucci, Università della Calabria, I-87036 Arcavacata di Rende (CS), Italy. ² Dipartimento di Scienze Farmaceutiche, Via P. Bucci, Università della Calabria, I-87036 Arcavacata di Rende (CS), Italy. ³ Dipartimento di Scienze Farmaceutiche, Via P. Bucci, Università della Calabria, I-87036 Arcavacata di Rende (CS), Italy. ⁴ Dipartimento di Scienze Farmaceutiche, Via P. Bucci, Università della Calabria, I-87036 Arcavacata di Rende (CS), Italy. ⁵ Dipartimento di Scienze Farmaceutiche, Via P. Bucci, Università della Calabria, I-87036 Arcavacata di Rende (CS), Italy. ⁶ Dipartimento di Scienze Farmaceutiche, Via P. Bucci, Università della Calabria, I-87036 Arcavacata di Rende (CS), Italy.
Source: Letters in Organic Chemistry, Volume 3, Issue 6, Jun 2006, p. 468 - 469
DOI: https://doi.org/10.2174/157017806777828466
- Available online: 01 Jun 2006

Abstract

Aromatic and aliphatic Weinreb amides are selectively converted into the corresponding N-methoxy- N-methylamines by treatment with lithium aluminium hydride in the presence of aluminium chloride.

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2006-06-01

2025-10-12

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Article Type: Research Article

Keyword(s): aluminum chloride; lithium aluminium hydride; N-Methoxy-N-methylamines; reduction; Weinreb amides

Reduction of N-Methoxy-N-Methylamides to the Corresponding Amines with AlCl3/LiAlH4

Abstract

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