A Concise Total Synthesis of 7-Substituted Eudistomin Analogs

Zuozhong Peng; Ji Song; Wensheng Liao; Rujian Ma; Shu-Hui Chen; Ge Li; Ryoichi Ando

doi:10.2174/157017806777828448

ISSN: 1570-1786
E-ISSN: 1875-6255

A Concise Total Synthesis of 7-Substituted Eudistomin Analogs
Authors: Zuozhong Peng¹, Ji Song², Wensheng Liao³, Rujian Ma⁴, Shu-Hui Chen⁵, Ge Li⁶ and Ryoichi Ando⁷
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¹ WuXi PharmaTech Co.,Ltd., No. 1 Building, 288 FuTe ZhongLu, WaiGaoQiao Free Trade Zone,Shanghai, 200131, P. R. China. ² WuXi PharmaTech Co.,Ltd., No. 1 Building, 288 FuTe ZhongLu, WaiGaoQiao Free Trade Zone,Shanghai, 200131, P. R. China. ³ WuXi PharmaTech Co.,Ltd., No. 1 Building, 288 FuTe ZhongLu, WaiGaoQiao Free Trade Zone,Shanghai, 200131, P. R. China. ⁴ WuXi PharmaTech Co.,Ltd., No. 1 Building, 288 FuTe ZhongLu, WaiGaoQiao Free Trade Zone,Shanghai, 200131, P. R. China. ⁵ WuXi PharmaTech Co.,Ltd., No. 1 Building, 288 FuTe ZhongLu, WaiGaoQiao Free Trade Zone,Shanghai, 200131, P. R. China. ⁶ WuXi PharmaTech Co.,Ltd., No. 1 Building, 288 FuTe ZhongLu, WaiGaoQiao Free Trade Zone,Shanghai, 200131, P. R. China. ⁷ WuXi PharmaTech Co.,Ltd., No. 1 Building, 288 FuTe ZhongLu, WaiGaoQiao Free Trade Zone,Shanghai, 200131, P. R. China.
Source: Letters in Organic Chemistry, Volume 3, Issue 6, Jun 2006, p. 455 - 458
DOI: https://doi.org/10.2174/157017806777828448
- Available online: 01 Jun 2006

Abstract

We report herein an optimized practical synthesis of three novel 7-substituted eudistomin analogs (1-3). The total syntheses of these complex tetracyclic molecules were completed in 22 steps from the requisite 7-substituted indoles.

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2006-06-01

2025-10-12

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Article Type: Research Article

Keyword(s): demethylation; diasteroselectivity; Eudistomin analogs; Pictet-Spengler cyclization; total Synthesis

A Concise Total Synthesis of 7-Substituted Eudistomin Analogs

Abstract

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