Stereoselective Synthesis of C3-C10 and C13-C21 Fragments of Laulimalide

Sreenivas Punna; Rakesh; Anabathula Prabhakar; Gangavaram V. M. Sharma; Ajit Chand Kunwar

doi:10.2174/157017806777828411

ISSN: 1570-1786
E-ISSN: 1875-6255

Stereoselective Synthesis of C3-C10 and C13-C21 Fragments of Laulimalide
Authors: Sreenivas Punna¹, Rakesh², Anabathula Prabhakar³, Gangavaram V. M. Sharma⁴ and Ajit Chand Kunwar⁵
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¹ D 211, Discovery Laboratory, Organic Chemistry Division III Indian Institute of Chemical Technology, Hyderabad 500 007, India. ² D 211, Discovery Laboratory, Organic Chemistry Division III Indian Institute of Chemical Technology, Hyderabad 500 007, India. ³ D 211, Discovery Laboratory, Organic Chemistry Division III Indian Institute of Chemical Technology, Hyderabad 500 007, India. ⁴ D 211, Discovery Laboratory, Organic Chemistry Division III Indian Institute of Chemical Technology, Hyderabad 500 007, India. ⁵ D 211, Discovery Laboratory, Organic Chemistry Division III Indian Institute of Chemical Technology, Hyderabad 500 007, India.
Source: Letters in Organic Chemistry, Volume 3, Issue 6, Jun 2006, p. 447 - 454
DOI: https://doi.org/10.2174/157017806777828411
- Available online: 01 Jun 2006

Abstract

Synthesis of the C3-C10 and C13-C21 segments, having seven asymmetric centers of the marine macrolide, (-)-laulimalide is reported. The requisite stereogenic centers were generated on the chirons by the application of asymmetric reactions.

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2006-06-01

2025-10-12

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Article Type: Research Article

Keyword(s): chiron; intramolecular cyclization; laulimalide; Marine macrolide; Sharpless asymmetric epoxidation; stereoselective synthesis

Stereoselective Synthesis of C3-C10 and C13-C21 Fragments of Laulimalide

Abstract

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