One-Pot Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones Using Hydrochloric Acid- β-Cyclodextrin- Combined Catalysts

Haixia Zhou; Miao He; Chunsheng Liu; Genxiang Luo

doi:10.2174/157017806775789985

ISSN: 1570-1786
E-ISSN: 1875-6255

One-Pot Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones Using Hydrochloric Acid- β-Cyclodextrin- Combined Catalysts
Authors: Haixia Zhou¹, Miao He², Chunsheng Liu³ and Genxiang Luo⁴
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¹ Department of Chemistry, Liaoning University of Petroleum and Chemical Technology, Fushun, Liaoning, 113001, P. R. China. ² Department of Chemistry, Liaoning University of Petroleum and Chemical Technology, Fushun, Liaoning, 113001, P. R. China. ³ Department of Chemistry, Liaoning University of Petroleum and Chemical Technology, Fushun, Liaoning, 113001, P. R. China. ⁴ Department of Chemistry, Liaoning University of Petroleum and Chemical Technology, Fushun, Liaoning, 113001, P. R. China.
Source: Letters in Organic Chemistry, Volume 3, Issue 3, Mar 2006, p. 225 - 227
DOI: https://doi.org/10.2174/157017806775789985
- Available online: 01 Mar 2006

Abstract

An improved approach has been found to carry out the Biginelli reaction for the synthesis of 3,4- dihydropyrimidin- 2(1H)-one derivatives. This synthesis was performed in the presence of hydrochloric acid and β-cyclodextrin in ethanol solution. Compared with the classical Biginelli reaction conditions, this new approach has the advantage of excellent yields and short reaction time.

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2006-03-01

2025-09-06

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Article Type: Research Article

Keyword(s): Biginelli reaction; Dihydropyrimidinones; One-pot; Synthesis; β-cyclodextrin

One-Pot Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones Using Hydrochloric Acid- β-Cyclodextrin- Combined Catalysts

Abstract

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