Indium Triflate Catalysed Ene and Friedel Crafts Additions to α-Imino Esters: A One-Pot Synthesis of α-Amino Acid Derivatives

Kamlesh K. Chauhan; Joseph P. Hartley; Matthew Krakowski; Christopher G. Frost

doi:10.2174/157017806775789921

ISSN: 1570-1786
E-ISSN: 1875-6255

Indium Triflate Catalysed Ene and Friedel Crafts Additions to α-Imino Esters: A One-Pot Synthesis of α-Amino Acid Derivatives
Authors: Kamlesh K. Chauhan¹, Joseph P. Hartley², Matthew Krakowski³ and Christopher G. Frost⁴
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¹ Department of Chemistry, University of Bath, Claverton Down, Bath BA2 7AY, UK. ² Department of Chemistry, University of Bath, Claverton Down, Bath BA2 7AY, UK. ³ Department of Chemistry, University of Bath, Claverton Down, Bath BA2 7AY, UK. ⁴ Department of Chemistry, University of Bath, Claverton Down, Bath BA2 7AY, UK.
Source: Letters in Organic Chemistry, Volume 3, Issue 3, Mar 2006, p. 228 - 230
DOI: https://doi.org/10.2174/157017806775789921
- Available online: 01 Mar 2006

Abstract

The indium catalysed additions of electron-rich alkenes and heteroaromatics to an activated α-imino ester is described. The moisture-sensitive substrate is prepared in situ facilitating a convenient synthesis of unnatural α-amino acid derivatives in one-pot from commercially available reagents.

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2006-03-01

2025-10-26

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Article Type: Research Article

Keyword(s): Catalysis; Friedel-Crafts; Imino-ene; Indium; Lewis acid

Indium Triflate Catalysed Ene and Friedel Crafts Additions to α-Imino Esters: A One-Pot Synthesis of α-Amino Acid Derivatives

Abstract

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