Synthesis of β-Amino Alcohols by Regioselective Ring Opening of Epoxides with Aromatic Amines Catalyzed by Tin (II) Chloride [1]

Tin (II) chloride dihydrate catalyses the nucleophilic ring opening of epoxide by aromatic amines leading to an efficient synthesis of β-amino alcohols in very good yields. The reactions are completely antistereoselective, highly regioselctive and proceed at ambient temperature which make this procedure particularly an alternative strategy for the synthesis of β-amino alcohols.