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- ISSN: 1570-1786
- E-ISSN: 1875-6255
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Synthesis of C7-Substituted Estra-1,3,5(10),6-Tetraen-3,17 β-Diols
- Source: Letters in Organic Chemistry, Volume 3, Issue 3, Mar 2006, p. 214 - 219
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- 01 Mar 2006
Abstract
A series of C7-substituted estra-1,3,5(10),6-tetraene-3,17β-diols were prepared as precursors to radiodiagnostic agents of breast cancer. The introduction of the olefin moiety at C6/C7 in the molecules was achieved through thermal elimination of the 6-hydroxy group in the corresponding estra-1,3,5(10)-triene- 3,17β-diols.
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