Efficient Microwave and Phosphane-Free Synthesis of Trisubstituted Olefins via Heck Coupling

Simona Collina; Mariangela Urbano; Andrea Magnani; Guya Loddo; Ornella Azzolina

doi:10.2174/157017806774964549

ISSN: 1570-1786
E-ISSN: 1875-6255

Efficient Microwave and Phosphane-Free Synthesis of Trisubstituted Olefins via Heck Coupling
Authors: Simona Collina¹, Mariangela Urbano², Andrea Magnani³, Guya Loddo⁴ and Ornella Azzolina⁵
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¹ Dipartimento di Chimica Farmaceutica, Universita di Pavia, Viale Taramelli 12, 27100, Pavia, Italy. ² Dipartimento di Chimica Farmaceutica, Universita di Pavia, Viale Taramelli 12, 27100, Pavia, Italy. ³ Dipartimento di Chimica Farmaceutica, Universita di Pavia, Viale Taramelli 12, 27100, Pavia, Italy. ⁴ Dipartimento di Chimica Farmaceutica, Universita di Pavia, Viale Taramelli 12, 27100, Pavia, Italy. ⁵ Dipartimento di Chimica Farmaceutica, Universita di Pavia, Viale Taramelli 12, 27100, Pavia, Italy.
Source: Letters in Organic Chemistry, Volume 3, Issue 1, Jan 2006, p. 16 - 20
DOI: https://doi.org/10.2174/157017806774964549
- Available online: 01 Jan 2006

Abstract

We describe an easy and convenient procedure for palladium-catalyzed Heck arylation of disubstituted olefins via microwave irradiation. This method of synthesis produces trisubstituted olefins under phosphane-free conditions and in very short times.

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2006-01-01

2025-09-23

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Article Type: Research Article

Keyword(s): chemical library; Heck reaction; microwave irradiation; phosphane-free procedure; trisubstituted olefins

Efficient Microwave and Phosphane-Free Synthesis of Trisubstituted Olefins via Heck Coupling

Abstract

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