Short Synthesis of the Selective Rho-Kinase Inhibitor Y-27632 and of Its Enantiomer

D. Belotti; J. L. Peglion; J. Cossy

doi:10.2174/157017805774297019

ISSN: 1570-1786
E-ISSN: 1875-6255

Short Synthesis of the Selective Rho-Kinase Inhibitor Y-27632 and of Its Enantiomer
Authors: D. Belotti¹, J. L. Peglion² and J. Cossy³
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¹ Laboratoire de Chimie Organique associe au CNRS, ESPCI, 10 rue Vauquelin, 75231 Paris Cedex 05, France. ² Laboratoire de Chimie Organique associe au CNRS, ESPCI, 10 rue Vauquelin, 75231 Paris Cedex 05, France. ³ Laboratoire de Chimie Organique associe au CNRS, ESPCI, 10 rue Vauquelin, 75231 Paris Cedex 05, France.
Source: Letters in Organic Chemistry, Volume 2, Issue 7, Nov 2005, p. 634 - 636
DOI: https://doi.org/10.2174/157017805774297019
- Available online: 01 Nov 2005

Abstract

Y-27632 and its enantiomer were synthesized in 8 steps from trans-1,4-cyclohexanedicarboxylic acid by using a diastereoselective reductive amination of a ketone.

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2005-11-01

2025-09-06

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Article Type: Review Article

Keyword(s): kinase inhibitor; reductive amination; rho-associated kinase

Short Synthesis of the Selective Rho-Kinase Inhibitor Y-27632 and of Its Enantiomer

Abstract

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