A Simple Asymmetric Synthesis of 4-Substituted-2-Oxazolidinones

V. J. Sattigeri; A. S.S.V. Srinivas; A. Soni; J. M. Khanna; A. Mehta

doi:10.2174/157017805774296876

ISSN: 1570-1786
E-ISSN: 1875-6255

A Simple Asymmetric Synthesis of 4-Substituted-2-Oxazolidinones
Authors: V. J. Sattigeri¹, A. S.S.V. Srinivas², A. Soni³, J. M. Khanna⁴ and A. Mehta⁵
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¹ Department of Medicinal Chemistry, Ranbaxy Research Laboratories, Plot no 20, Sector 18, Udyog Vihar, Gurgaon -122001, Haryana, India. ² Department of Medicinal Chemistry, Ranbaxy Research Laboratories, Plot no 20, Sector 18, Udyog Vihar, Gurgaon -122001, Haryana, India. ³ Department of Medicinal Chemistry, Ranbaxy Research Laboratories, Plot no 20, Sector 18, Udyog Vihar, Gurgaon -122001, Haryana, India. ⁴ Department of Medicinal Chemistry, Ranbaxy Research Laboratories, Plot no 20, Sector 18, Udyog Vihar, Gurgaon -122001, Haryana, India. ⁵ Department of Medicinal Chemistry, Ranbaxy Research Laboratories, Plot no 20, Sector 18, Udyog Vihar, Gurgaon -122001, Haryana, India.
Source: Letters in Organic Chemistry, Volume 2, Issue 7, Nov 2005, p. 637 - 639
DOI: https://doi.org/10.2174/157017805774296876
- Available online: 01 Nov 2005

Abstract

A novel and efficient synthesis of 4-substituted 2-oxazolidinones is described; the synthesis utilizes Sharpless asymmetric dihydroxylation (AD) of appropriately substituted O-allylcarbamates and intramolecular cyclisation as key steps.

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2005-11-01

2025-09-11

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Article Type: Review Article

Keyword(s): asymmetric dihydroxylation; chiral; intramolecular cyclisation; substituted -oxazolidinones

A Simple Asymmetric Synthesis of 4-Substituted-2-Oxazolidinones

Abstract

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