One-Pot Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones Using ZnCl2, CuCl2, NiCl2 and CoCl2 Doped Hydroxyapatite

H. El Badaoui; F. Bazi; S. Sokori; S. Boulaajaj; H. B. Lazrek; S. Sebti

doi:10.2174/1570178054640750

ISSN: 1570-1786
E-ISSN: 1875-6255

One-Pot Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones Using ZnCl2, CuCl2, NiCl2 and CoCl2 Doped Hydroxyapatite
Authors: H. El Badaoui¹, F. Bazi², S. Sokori³, S. Boulaajaj⁴, H. B. Lazrek⁵ and S. Sebti⁶
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¹ Laboratoire de Chimie Organique Catalyse et Environnement, Universite Hassan II, Faculte des Sciences Ben M'Sik B.P. 7955, 20702 Casablanca, Morocco; ² Laboratoire de Chimie Organique Catalyse et Environnement, Universite Hassan II, Faculte des Sciences Ben M'Sik B.P. 7955, 20702 Casablanca, Morocco; ³ Laboratoire de Chimie Organique Catalyse et Environnement, Universite Hassan II, Faculte des Sciences Ben M'Sik B.P. 7955, 20702 Casablanca, Morocco; ⁴ Laboratoire de Chimie Organique Catalyse et Environnement, Universite Hassan II, Faculte des Sciences Ben M'Sik B.P. 7955, 20702 Casablanca, Morocco; ⁵ Laboratoire de Chimie Organique Catalyse et Environnement, Universite Hassan II, Faculte des Sciences Ben M'Sik B.P. 7955, 20702 Casablanca, Morocco; ⁶ Laboratoire de Chimie Organique Catalyse et Environnement, Universite Hassan II, Faculte des Sciences Ben M'Sik B.P. 7955, 20702 Casablanca, Morocco;
Source: Letters in Organic Chemistry, Volume 2, Issue 6, Sep 2005, p. 561 - 565
DOI: https://doi.org/10.2174/1570178054640750
- Available online: 01 Sep 2005

Abstract

Hydroxyapatite doped with ZnCl2, CuCl2, NiCl2 and CoCl2 efficiently catalyses the three components Biginelli reaction between an aldehyde, ethyl acetoacetate and urea in refluxing toluene to afford the corresponding dihydropyrimidinones in high yields.

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2005-09-01

2025-09-03

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Article Type: Review Article

Keyword(s): biginelli reaction; dihydropyrimidinones; heterogeneous catalysis; hydroxyapatite; lewis acids

One-Pot Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones Using ZnCl2, CuCl2, NiCl2 and CoCl2 Doped Hydroxyapatite

Abstract

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