FeCl3 and FeCl3-SiO2 Catalysed Selective p-Methoxybenzylation of Alcohols with p-Methoxybenzyl Alcohol (PMB-OH)#

Palakodety R. Krishna; B. Lavanya; A. K. Mahalingam; V.V. Ramana Reddy; G. V.M. Sharma

doi:10.2174/1570178054038939

ISSN: 1570-1786
E-ISSN: 1875-6255

FeCl3 and FeCl3-SiO2 Catalysed Selective p-Methoxybenzylation of Alcohols with p-Methoxybenzyl Alcohol (PMB-OH)#
Authors: Palakodety R. Krishna¹, B. Lavanya², A. K. Mahalingam³, V.V. Ramana Reddy⁴ and G. V.M. Sharma⁵
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¹ D 206/B, Discovery Laboratory, Organic Chemistry Division-III, Indian Institute of Chemical Technology, Hyderabad-500 007, India. ² D 206/B, Discovery Laboratory, Organic Chemistry Division-III, Indian Institute of Chemical Technology, Hyderabad-500 007, India. ³ D 206/B, Discovery Laboratory, Organic Chemistry Division-III, Indian Institute of Chemical Technology, Hyderabad-500 007, India. ⁴ D 206/B, Discovery Laboratory, Organic Chemistry Division-III, Indian Institute of Chemical Technology, Hyderabad-500 007, India. ⁵ D 206/B, Discovery Laboratory, Organic Chemistry Division-III, Indian Institute of Chemical Technology, Hyderabad-500 007, India.
Source: Letters in Organic Chemistry, Volume 2, Issue 4, Jun 2005, p. 360 - 363
DOI: https://doi.org/10.2174/1570178054038939
- Available online: 01 Jun 2005

Abstract

Anhydrous FeCl3 and FeCl3-SiO2 serve as Lewis acids for direct conversion of alcohols into pmethoxybezyl ethers using PMB-OH in good yields, the latter reagent was found to be effective in not only converting primary, allylic and propargylic alcohols selectively but also the pre-existing acid sensitive groups remained unscathed.

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2005-06-01

2025-09-13

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Article Type: Review Article

Keyword(s): benzyl ethers; catalytic ddq; deprotection; lewis acid; nucleophilic attack; p-methoxybenzyl (pmb); pmb alcohol

FeCl3 and FeCl3-SiO2 Catalysed Selective p-Methoxybenzylation of Alcohols with p-Methoxybenzyl Alcohol (PMB-OH)#

Abstract

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