Chemoselective Carbonyl Benzylation Mediated by Zn / CdCl2 / InCl3 in Tap Water

Cunliu Zhou; Jiaoyang Jiang; Yuqing Zhou; Zhen Xie; Qian Miao; Zhiyong Wang

doi:10.2174/1570178053400072

ISSN: 1570-1786
E-ISSN: 1875-6255

Chemoselective Carbonyl Benzylation Mediated by Zn / CdCl2 / InCl3 in Tap Water
Authors: Cunliu Zhou¹, Jiaoyang Jiang², Yuqing Zhou³, Zhen Xie⁴, Qian Miao⁵ and Zhiyong Wang⁶
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¹ Department of Chemistry, University of Science & Technology of China, Hefei, 230026, China. ² Department of Chemistry, University of Science & Technology of China, Hefei, 230026, China. ³ Department of Chemistry, University of Science & Technology of China, Hefei, 230026, China. ⁴ Department of Chemistry, University of Science & Technology of China, Hefei, 230026, China. ⁵ Department of Chemistry, University of Science & Technology of China, Hefei, 230026, China. ⁶ Department of Chemistry, University of Science & Technology of China, Hefei, 230026, China.
Source: Letters in Organic Chemistry, Volume 2, Issue 1, Feb 2005, p. 61 - 64
DOI: https://doi.org/10.2174/1570178053400072
- Available online: 01 Feb 2005

Abstract

A novel tri-metal system (Zn / CdCl2 / InCl3) has been developed as an effective mediator in the benzylations of various aldehydes in tap water to afford the corresponding alcohols. It can selectively mediate the benzylation of aldehyde in the presence of ketone. CdCl2 and InCl3 are easily recycled and used in this reaction without further purification.

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2005-02-01

2025-10-05

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Article Type: Review Article

Keyword(s): barbier reaction; benzylation; carbonyl compound; chemoselective addition; tri-metal system; water

Chemoselective Carbonyl Benzylation Mediated by Zn / CdCl2 / InCl3 in Tap Water

Abstract

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