Enantioselective Copper-catalysed Conjugate Addition of Diphenylzinc to Cyclohexenone

Xiao-yu Wu; Xiang-guo Li; Gang Zhao

doi:10.2174/1570178053400054

ISSN: 1570-1786
E-ISSN: 1875-6255

Enantioselective Copper-catalysed Conjugate Addition of Diphenylzinc to Cyclohexenone
Authors: Xiao-yu Wu¹, Xiang-guo Li² and Gang Zhao³
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¹ State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences 354 Fenglin Lu, Shanghai 200032, China. ² State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences 354 Fenglin Lu, Shanghai 200032, China. ³ State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences 354 Fenglin Lu, Shanghai 200032, China.
Source: Letters in Organic Chemistry, Volume 2, Issue 1, Feb 2005, p. 65 - 67
DOI: https://doi.org/10.2174/1570178053400054
- Available online: 01 Feb 2005

Abstract

The copper-catalysed asymmetric conjugate addition of diphenylzinc to 2-cyclohexenone has been carried out with good results. An enantiometric excess of up to 91% was obtained using 5 mol% CuI and 5 mol% phosphine ligand derived from L-proline.

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2005-02-01

2025-10-05

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Article Type: Review Article

Keyword(s): conjugate-addition; copper-catalyzed; diphenylzinc; ligand; phosphine

Enantioselective Copper-catalysed Conjugate Addition of Diphenylzinc to Cyclohexenone

Abstract

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