Skip to content
2000
image of Next-Generation Plant Constituents Delivery by Harnessing Liquisolid Technology for Optimal Pharmaceutical Outcomes: A Review

Abstract

The effectiveness of herbal preparations depends on achieving therapeutic plasma concentrations. The efficacy of phytoconstituents is often hindered by poor lipid solubility, high molecular weight, or degradation in the gastric environment. The liquisolid system is a promising technique for developing herbal pharmaceuticals due to its simple manufacturing process, low production costs, industrial viability, excellent flow and compaction properties, and ability to protect active ingredients from oxidation. The liquisolid technique converts liquid formulations, suspensions, or solutions into dry, free-flowing, and compressible powder blends. This approach enhances drug dissolution rates, maintains the photostability of phytoconstituents, and protects against humidity, thereby extending shelf-life. However, the technique faces challenges, such as carefully selecting excipients and difficulties with high-dose formulations. Overcoming these challenges is crucial to improving the therapeutic efficacy of phytoconstituents in pharmaceutical applications. This review explores the liquisolid technique for phytoconstituent drug delivery by conducting an extensive literature analysis using PubMed, CrossRef, and Google Scholar databases. Advances in excipient selection and formulation strategies can significantly enhance the therapeutic potential of herbal treatments employing liquisolid technology, fostering the development of advanced drug delivery systems in modern pharmaceuticals.

© 2025 Bentham Science Publishers
Loading

Article metrics loading...

/content/journals/loc/10.2174/0115701786365794250717080612
2025-07-29
2025-09-17

  • From This Site

    /content/journals/loc/10.2174/0115701786365794250717080612
    dcterms_title,dcterms_subject,pub_keyword
    -contentType:Contributor -contentType:Concept -contentType:Institution
    10
    5
Loading full text...

Full text loading...

References

  1. Horáčková L. Chmelíčková K. Hermannová M. Pitucha T. Vágnerová H. Židek O. Velebný V. Chmelař J. Water-insoluble fibres, threads, and fabrics from lauroyl derivatives of hyaluronan. Int. J. Biol. Macromol. 2023 234 123654 10.1016/j.ijbiomac.2023.123654 36780961
    [Google Scholar]
  2. Han J. Zhang S. He J. Li T. Piperine: Chemistry and biology. Toxins 2023 15 12 696 10.3390/toxins15120696 38133200
    [Google Scholar]
  3. Faizan M. Moazzam I. Advancements in Liquisolid Compacts Technology Formulation and Characterization. Indian J. Pharma. Educat. Res. 2024 3 3 220 237
    [Google Scholar]
  4. Kazmi I. Al-Abbasi F.A. Imam S.S. Afzal M. Nadeem M.S. Altayb H.N. Alshehri S. Formulation of piperine nanoparticles: In vitro breast cancer cell line and in vivo evaluation. Polymers 2022 14 7 1349 10.3390/polym14071349 35406223
    [Google Scholar]
  5. Ogadah CU Development of liquisolid systems for colon targeting. Doctoral thesis review, Department of Pharmaceutical Technology Faculty of Pharmacy in Hradec Králové Charles University 2021
    [Google Scholar]
  6. Mohana B.B. Maddi E.G. Dang R. Formulation and evaluation of fast dissolving tablets of oxcarbazepine using liquisolid technology. Indian J. Pharma. Educat. Res. 2024 58 3s s880 s889 10.5530/ijper.58.3s.89
    [Google Scholar]
  7. Lou Y. Yu K. Wu X. Wang Z. Cui Y. Bao H. Wang J. Hu X. Ji Y. Tang G. Co-crystals of resveratrol and polydatin with L-proline: Crystal structures, dissolution properties, and in vitro cytotoxicities. Molecules 2021 26 18 5722 10.3390/molecules26185722 34577193
    [Google Scholar]
  8. Verma P. Chandra A. Pandey G. Diversity-oriented approach toward the syntheses of Amaryllidaceae alkaloids via a common chiral synthon. J. Org. Chem. 2018 83 17 9968 9977 10.1021/acs.joc.8b01368 30005155
    [Google Scholar]
  9. Kaur A. Verma S. Paramesh D.B. Mahammad N. Development and characterization of liquisolid compact to improve dissolution of an antihypertensive drug. Indian J. Pharma. Educat. Res. 2024 58 4 1198 1204 10.5530/ijper.58.4.132
    [Google Scholar]
  10. Fitriani L. Tirtania S. Umar S. Zaini E. Enhancing the solubility and dissolution rate of piperine via preparation of piperine–hydroxypropyl methylcellulose 2910 solid dispersion system using freeze-drying method. J. Pharm. Pharmacogn. Res. 2024 12 1 175 183 10.56499/jppres23.1734_12.1.175
    [Google Scholar]
  11. Stasiłowicz A. Rosiak N. Tykarska E. Kozak M. Jenczyk J. Szulc P. Kobus-Cisowska J. Lewandowska K. Płazińska A. Płaziński W. Cielecka-Piontek J. Combinations of piperine with hydroxypropyl-β-cyclodextrin as a multifunctional system. Int. J. Mol. Sci. 2021 22 8 4195 10.3390/ijms22084195 33919582
    [Google Scholar]
  12. Yu Y. Wei R. Jia X. Zhang X. Liu H. Xu B. Xu B. Preparation of piper nigrum microcapsules by spray drying and optimization with response surface methodology. J. Oleo Sci. 2022 71 12 1789 1797 10.5650/jos.ess21299 36336340
    [Google Scholar]
  13. Konieczna D.D. Biller H. Witte M. Schmidt W.G. Neuba A. Wilhelm R. New pyridinium based ionic dyes for the hydrogen evolution reaction. Tetrahedron 2018 74 1 142 149 10.1016/j.tet.2017.11.053
    [Google Scholar]
  14. Imam S.S. Alshehri S. Altamimi M.A. Hussain A. Qamar W. Gilani S.J. Zafar A. Alruwaili N.K. Alanazi S. Almutairy B.K. Formulation of piperine–chitosan-coated liposomes: Characterization and in vitro cytotoxic evaluation. Molecules 2021 26 11 3281 10.3390/molecules26113281 34072306
    [Google Scholar]
  15. Vemula S.K. Radhika K. Liquisolid compact technique for improvement of the dissolution rate of flurbiprofen: Formulation and evaluation. J Drug Res Dev. 2015 1 1 2470 1009
    [Google Scholar]
  16. Chaudhary N. Tripathi D. Rai A.K. A technical approach of solubility enhancement of poorly soluble drugs: Liquisolid technique. Curr. Drug Deliv. 2020 17 8 638 650 10.2174/1567201817666200516155733 32416691
    [Google Scholar]
  17. Lu M. Xing H. Jiang J. Chen X. Yang T. Wang D. Ding P. Liquisolid technique and its applications in pharmaceutics. Asian J. Pharm. Sci. 2017 12 2 115 123 10.1016/j.ajps.2016.09.007 32104320
    [Google Scholar]
  18. Elkordy A.A. Tan X.N. Essa E.A. Spironolactone release from liquisolid formulations prepared with Capryol™ 90, Solutol® HS-15 and Kollicoat® SR 30 D as non-volatile liquid vehicles. Eur. J. Pharm. Biopharm. 2013 83 2 203 223 10.1016/j.ejpb.2012.08.004 22960707
    [Google Scholar]
  19. Vraníková B. Gajdziok J. Vetchý D. Modern evaluation of liquisolid systems with varying amounts of liquid phase prepared using two different methods. BioMed Res. Int. 2015 2015 1 12 10.1155/2015/608435 26075249
    [Google Scholar]
  20. Aleksić I. German Ilić I. Cvijić S. Parojčić J. An investigation into the influence of process parameters and formulation variables on compaction properties of liquisolid systems. AAPS PharmSciTech 2020 21 7 242 10.1208/s12249‑020‑01781‑2
    [Google Scholar]
  21. Jaydip B. Dhaval M. Soniwala M.M. Chavda J. Formulation and optimization of liquisolid compact for enhancing dissolution properties of efavirenz by using DoE approach. Saudi Pharm. J. 2020 28 6 737 745 10.1016/j.jsps.2020.04.016 32550806
    [Google Scholar]
  22. Tayel S.A. Soliman I.I. Louis D. Improvement of dissolution properties of Carbamazepine through application of the liquisolid tablet technique. Eur. J. Pharm. Biopharm. 2008 69 1 342 347 10.1016/j.ejpb.2007.09.003 17949959
    [Google Scholar]
  23. Spireas S. Hygrosol pharmaceutical corp, assignee. Liquisolid systems and methods of preparing same. US Patent 6,423,339 2002
  24. Tripathi D. Mishra S. Rai A.K. Sahoo J. Sharma D.K. Singh Y. Curcumin-loaded hydrotropic solid dispersion topical gel development and evaluation: A greener approach towards Transdermal delivery of drugs. Curr. Green Chem. 2022 9 1 26 39 10.2174/2213346110666221020121020
    [Google Scholar]
  25. Ogadah C.U. Mrštná K. Matysová L. Müllertz A. Rades T. Niederquell A. Šklubalová Z. Vraníková B. Comparison of the liquisolid technique and co-milling for loading of a poorly soluble drug in inorganic porous excipients. Int. J. Pharm. 2024 650 123702 10.1016/j.ijpharm.2023.123702 38086492
    [Google Scholar]
  26. Adefegha S.A. Oyediran J.A. Oboh G. Piperine abates cognitive dysfunction via modulation of key enzymes relevant to neurodegeneration in scopolamine-induced rats. Comp. Clin. Pathol. 2023 32 3 451 460 10.1007/s00580‑023‑03456‑3
    [Google Scholar]
  27. Mitra S. Anand U. Jha N.K. Shekhawat M.S. Saha S.C. Nongdam P. Rengasamy K.R.R. Proćków J. Dey A. Anticancer applications and pharmacological properties of piperidine and piperine: A comprehensive review on molecular mechanisms and therapeutic perspectives. Front. Pharmacol. 2022 12 772418 10.3389/fphar.2021.772418 35069196
    [Google Scholar]
  28. Chandel P. Kumari R. Kapoor A. Liquisolid technique: An approach for enhancement of solubility. J. Drug Deliv. Ther. 2013 3 4 131 137 10.22270/jddt.v3i4.556
    [Google Scholar]
  29. Sari D.R. Wardhana Y.W. Rusdiana T. Enhancement of solubility BCS class II and IV pharmaceuticals by liqusolid technique: A review. Indones. J. Pharm. 2020 2 2 77 88
    [Google Scholar]
  30. Patil U. Mudavath H. Patil S. Jadatkar K. Kumar G. Patel S. Liquisolid compact: A review. Int. J. Pharm. Res. Dev. 2012 4 3 151 157
    [Google Scholar]
  31. Li X.S. Wang J.X. Shen Z.G. Zhang P.Y. Chen J.F. Yun J. Preparation of uniform prednisolone microcrystals by a controlled microprecipitation method. Int. J. Pharm. 2007 342 1-2 26 32 10.1016/j.ijpharm.2007.04.025 17566675
    [Google Scholar]
  32. Karmarkar A.B. Gonjari I.D. Hosmani A.H. Dhabale P.N. Evaluation of in vitro dissolution profile comparison methods of sustained release tramadol hydrochloride liquisolid compact formulations with marketed sustained release tablets. Drug Discov. Ther. 2010 4 1 26 32 22491149
    [Google Scholar]
  33. Gangode B.D. Ahirrao S. Chavan D. Jadhav A. Kshirsagar S. Liquisolid technique: An approach for enhancement of solubility. Indian J. Drugs. 2016 4 4 149 167
    [Google Scholar]
  34. Panda S. Varaprasad R. Priyanka K. Swain R.P. Liquisolid technique: A novel approach for dosage form design. Inter. J. Appl. Pharma. 2017 9 3 8 14 10.22159/ijap.2017v9i3.18698
    [Google Scholar]
  35. Lou J. Duan H. Qin Q. Teng Z. Gan F. Zhou X. Zhou X. Advances in oral drug delivery systems: Challenges and opportunities. Pharmaceutics 2023 15 2 484 10.3390/pharmaceutics15020484 36839807
    [Google Scholar]
  36. Zhang L Russell D Conway BR Batchelor H Strategies and therapeutic opportunities for the delivery of drugs to the esophagus. Crit. Rev. Ther. Drug Carrier. Syst. 2008 25 3 259 304 10.1615/CritRevTherDrugCarrierSyst.v25.i3.20
    [Google Scholar]
  37. Pandey P. Chaudhary R. Tripathi D. Lavudi K. Dua K. Weinfeld M. Lavasanifar A. Rajinikanth P.S. Personalized treatment approach for HER2-positive metastatic breast cancer. Med. Oncol. 2024 41 11 252 10.1007/s12032‑024‑02504‑4 39320608
    [Google Scholar]
  38. Tripathi D. Yadav P. Mishra G. Rai A.K. Experimental investigation on efficacy of eudragit RS 100 polymer in prolonging glibenclamide release by intragastric floating microsphere formulation and physicochemical evaluation. Micro Nanosyst. 2024 16 2 123 138 10.2174/0118764029286890240314060427
    [Google Scholar]
  39. Koziolek M. Grimm M. Becker D. Iordanov V. Zou H. Shimizu J. Wanke C. Garbacz G. Weitschies W. Investigation of pH and temperature profiles in the GI tract of fasted human subjects using the Intellicap® system. J. Pharm. Sci. 2015 104 9 2855 2863 10.1002/jps.24274 25411065
    [Google Scholar]
  40. El-Hammadi M. Awad N. Investigating the use of liquisolid compacts technique to minimize the influence of pH variations on loratadine release. AAPS PharmSciTech 2012 13 1 53 58 10.1208/s12249‑011‑9719‑6 22101967
    [Google Scholar]
  41. Kanugo A. Liquisolid-pellets technique: A recent technique for enhancing solubility and bioavailability of drugs. Inter. J. Appl. Pharma. 2020 7 34 40 10.22159/ijap.2020v12i6.39510
    [Google Scholar]
  42. Nazem N.M. Shokri J. Nourani N. Zangi A.R. Lam M. Nokhodchi A. Javadzadeh Y. Combining liquisolid and co-grinding techniques to enhance the dissolution rate of celecoxib. J. Pharm. Innov. 2023 18 1 300 309 10.1007/s12247‑022‑09641‑1
    [Google Scholar]
  43. Prusty A. Jena B.R. Barik V. Khamkat P. Barik B.B. Liquisolid technique for solubility enhancement of poorly soluble drug - A brief review. Curr. Drug Discov. Technol. 2024 22 1 8 10.2174/0115701638318659240923074614 39377384
    [Google Scholar]
  44. Baranauskaite J. Kopustinskiene D.M. Masteikova R. Gajdziok J. Baranauskas A. Bernatoniene J. Effect of liquid vehicles on the enhancement of rosmarinic acid and carvacrol release from oregano extract liquisolid compacts. Colloids Surf. A Physicochem. Eng. Asp. 2018 539 280 290 10.1016/j.colsurfa.2017.12.034
    [Google Scholar]
  45. Date A.A. Desai N. Dixit R. Nagarsenker M. Self-nanoemulsifying drug delivery systems: Formulation insights, applications and advances. Nanomedicine 2010 5 10 1595 1616 10.2217/nnm.10.126 21143036
    [Google Scholar]
  46. Jhaveri M. Nair A.B. Shah J. Jacob S. Patel V. Mehta T. Improvement of oral bioavailability of carvedilol by liquisolid compact: Optimization and pharmacokinetic study. Drug Deliv. Transl. Res. 2020 10 4 975 985 10.1007/s13346‑020‑00734‑3 32124413
    [Google Scholar]
  47. Agiba A.M. Liquisolid technology: A state-of-the-art review on the current state, challenges, new and emerging technologies for next generation. Curr. Drug Deliv. 2020 17 9 736 754 10.2174/1567201817999200729121914 32729418
    [Google Scholar]
  48. Rashad A. Louis D. An overview on liquisolid technique: Its development and applications. Ther. Deliv. 2022 13 12 577 589 10.4155/tde‑2022‑0057 36861309
    [Google Scholar]
  49. Aleksić I Glišić T Parojčić J Liquisolid systems as a novel approach in formulation and manufacturing of solid dosage forms: Challenges and perspectives. Arch. Pharma. 2022 72 6 521 545 10.5937/arhfarm72‑40329
    [Google Scholar]
  50. Taghizadeh Z. Rakhshani S. Jahani V. Rajabi O. Haghighi H.M. Abbaspour M. Preparation and in vitro characterization of carvacrol pellets by combination of liquisolid technique and extrusion-spheronization. J. Drug Deliv. Sci. Technol. 2021 61 102232 10.1016/j.jddst.2020.102232
    [Google Scholar]
  51. Burra S. Yamsani M. Vobalaboina V. The Liquisolid technique: An overview. Braz. J. Pharm. Sci. 2011 47 3 475 482 10.1590/S1984‑82502011000300005
    [Google Scholar]
  52. Rathva D Shah C Upadhyay U. A review on liquisolid compact technique. 2024
    [Google Scholar]
  53. Tripathi D. Sharma D.K. Sahoo J. Enhancing ketoprofen solubility: A strategic approach using solid dispersion and response surface methodology. Curr. Radiopharm. 2024 18 2 100 119 10.2174/0118744710311951241018054453 39449340
    [Google Scholar]
  54. Tong Y. Wang Y. Yang M. Yang J. Chen L. Chu X. Gao C. Jin Q. Gong W. Gao C. Systematic development of self-nanoemulsifying liquisolid tablets to improve the dissolution and oral bioavailability of an oily drug, vitamin K1. Pharmaceutics 2018 10 3 96 10.3390/pharmaceutics10030096 30021949
    [Google Scholar]
  55. Tripathi D. Chaudhary N. Kumar Sharma D. Sahoo J. An attempt to applying hydrotropy technique for titrimetric estimation of ketoprofen using sodium salicylate as hydrotrope. Res. J. Pharma. Tech. 2021 14 4 2277 2279 10.52711/0974‑360X.2021.00402
    [Google Scholar]
  56. Saeedi M. Akbari J. Semnani K. Hashemi S.M.H. Ghasemi S. Tahmasbi N. Azizpoor E. Faghani N. Rostamkalaei S.S. Nokhodchi A. Controlling atorvastatin release from liquisolid systems. J. Dispers. Sci. Technol. 2022 43 3 375 384 10.1080/01932691.2020.1842211
    [Google Scholar]
  57. Tønnesen H.H. Formulation and stability testing of photolabile drugs. Int. J. Pharm. 2001 225 1-2 1 14 10.1016/S0378‑5173(01)00746‑3 11489550
    [Google Scholar]
  58. Tripathi D. Pandey P. Sharma S. Rai A.K. Prabhu B H M. Advances in nanomaterials for precision drug delivery: Insights into pharmacokinetics and toxicity. Bioimpacts 2024 15 1 30573 10.34172/bi.30573 40256227
    [Google Scholar]
  59. Al-Okbi S.Y. Mohamed D.A. Hamed T.E.S. Abd El-Alim S.H. Kassem A.A. Mostafa D.M. Application of liquisolid technology for promoting the renoprotective efficacy of walnut extracts in chronic renal failure rat model. Drug Dev. Ind. Pharm. 2019 45 1 32 42 10.1080/03639045.2018.1515219 30132727
    [Google Scholar]
  60. Tripathi D. Chaudhary N. Sharma D.K. Sahoo J. Insightful investigative account on hydrotropic solubilization practice utilized for solubility management of poorly dissolvable drugs. Curr. Drug Ther. 2021 16 5 393 408 10.2174/1574885516666210914105024
    [Google Scholar]
  61. Patel Ub. Shah Cn. Patel Hm. Liquisolid compacts: An effective approach towards enhancement of dissolution rate of poorly soluble drugs. Pharma Sci. Monitor 2018 9 2 1 9
    [Google Scholar]
  62. Jagtap S Magdum C Jadge D Jagtap R. Solubility enhancement technique: A review. J. Pharm. Sci. Res. 2018 10 9 2205 2211
    [Google Scholar]
  63. Jadhav N.R. Irny P.V. Patil U.S. Solid state behavior of progesterone and its release from Neusilin US2 based liquisolid compacts. J. Drug Deliv. Sci. Technol. 2017 38 97 106 10.1016/j.jddst.2017.01.009
    [Google Scholar]
  64. Tripathi D. Gupta T. Pandey P. Exploring piperine: Unleashing the multifaceted potential of a phytochemical in cancer therapy. Mol. Biol. Rep. 2024 51 1 1050 10.1007/s11033‑024‑09978‑5 39395120
    [Google Scholar]
  65. Elmas A. Akyüz G. Bergal A. Andaç M. Andaç Ö. Mathematical modelling of drug release. Res. Eng. Struct. Mater. 2020 6 4 327 350
    [Google Scholar]
  66. Kaur M. Bala R. Arora S. Liquisolid technology: A review. Inter. J. Adv. Pharma. Sci. 2013 4 1 1 5
    [Google Scholar]
  67. Asuzu P.C. Trompeter N.S. Cooper C.R. Besong S.A. Aryee A.N.A. Cell culture-based assessment of toxicity and therapeutics of phytochemical antioxidants. Molecules 2022 27 3 1087 10.3390/molecules27031087 35164354
    [Google Scholar]
  68. Korni R. Voodikala S. Gonugunta C.S.R. Jayanti V. Liquisolid technique: An approach to enhance the dissolution rate of olanzapine. Indian J. Pharm. Sci. 2018 80 6 10.4172/pharmaceutical‑sciences.1000450
    [Google Scholar]
  69. Burra S. Galipelly S.K. Enhancement of solubility and dissolution rate of Frusemide through liquisolid technique. Sch. Res. Libr. 2010 2 6 321 328
    [Google Scholar]
  70. Yadav P.S. Hajare A.A. Patil K.S. Development of Doxazosin mesylate liquisolid system for improved manufacturing processability and bioavailability: In vitro and in vivo evaluation for tailored hypertension treatment approach with modified dissolution rates. J. Dispers. Sci. Technol. 2024 45 6 1227 1240 10.1080/01932691.2023.2203760
    [Google Scholar]
  71. Tripathi D. Chaudhary N. Wal P. Rai A.K. Sahoo J. Green hydrotropes-assisted route: An alternative approach for extracting phytoconstituents and associated drug delivery systems. Drug Deliv. Lett. 2021 11 3 220 232 10.2174/2210303111666210712100722
    [Google Scholar]
  72. Javadzadeh Y. Musaalrezaei L. Nokhodchi A. Liquisolid technique as a new approach to sustain propranolol hydrochloride release from tablet matrices. Int. J. Pharm. 2008 362 1-2 102 108 10.1016/j.ijpharm.2008.06.022 18647643
    [Google Scholar]
  73. Kulkarni AS Aloorkar NH Mane MS Gaja JB Liquisolid systems: A review. IJPSN 2010 3 1 1 8 10.37285/ijpsn.2010.3.1.1
    [Google Scholar]
  74. Fahmy R. Kassem M. Enhancement of famotidine dissolution rate through liquisolid tablets formulation: In vitro and in vivo evaluation. Eur. J. Pharm. Biopharm. 2008 69 3 993 1003 10.1016/j.ejpb.2008.02.017 18396390
    [Google Scholar]
  75. Yadav V.B. Yadav A.V. Enhancement of solubility and dissolution rate of BCS class II pharmaceuticals by nonaqueous granulation technique. Int. J. Pharm. Res. Dev. 2010 1 1 2
    [Google Scholar]
  76. Javadzadeh Y. Jafari-Navimipour B. Nokhodchi A. Liquisolid technique for dissolution rate enhancement of a high dose water-insoluble drug (carbamazepine). Int. J. Pharm. 2007 341 1-2 26 34 10.1016/j.ijpharm.2007.03.034 17498898
    [Google Scholar]
  77. Spireas S. Sadu S. Grover R. In vitro release evaluation of hydrocortisone liquisolid tablets. J. Pharm. Sci. 1998 87 7 867 872 10.1021/js970346g 9649356
    [Google Scholar]
  78. Song R.F. Li X.J. Cheng X.L. Fu A.R. Wang Y.H. Feng Y.J. Xiong Y. Paclitaxel-loaded trimethyl chitosan-based polymeric nanoparticle for the effective treatment of gastroenteric tumors. Oncol. Rep. 2014 32 4 1481 1488 10.3892/or.2014.3344 25051142
    [Google Scholar]
  79. Limpongsa E. Tabboon P. Pongjanyakul T. Jaipakdee N. Pondkule M.A. Babar V. Preparation and evaluation of directly compressible orally disintegrating tablets of cannabidiol formulated using liquisolid technique. Pharmaceutics 2022 14 11 2407 10.3390/pharmaceutics14112407 36365225
    [Google Scholar]
  80. Tripathi D Raman SK Sahoo J Sharma DK Rai AK Technical applications of hydrotropes: Sustainable and green carriers. Biointerf. Res. Appl. Chem. 2023 13 1 91 10.33263/BRIAC131.091
    [Google Scholar]
  81. Sharma S. Arora V. Sharma T. An effective approach to enhance the dissolution profile of curcumin and quercetin: Liquisolid compacts. Lett. Drug Des. Discov. 2024 21 7 1172 1184 10.2174/1570180820666230223101504
    [Google Scholar]
  82. Balaji AN Umashankar MS Kavitha B Liquisolid technology - A latest review. Inter. J. Appl. Pharma. 2014 6 1 11 19
    [Google Scholar]
  83. Siddiqui S. Khushtar M. Zafar A. Hasan S.M. Arshad M. Ahmad M.A. Kashif M. Mujahid M. Mechanism-based physiological effects of piperine: A review. Curr. Pharmacol. Rep. 2023 9 3 117 127 10.1007/s40495‑023‑00314‑2
    [Google Scholar]
  84. Badawy M.A. Kamel A.O. Sammour O.A. Use of biorelevant media for assessment of a poorly soluble weakly basic drug in the form of liquisolid compacts: In vitro and in vivo study. Drug Deliv. 2016 23 3 808 817 10.3109/10717544.2014.917442 24892630
    [Google Scholar]
  85. Sharma V. Pathak K. Liquisolid system of paclitaxel using modified polysaccharides: In vitro cytotoxicity, apoptosis study, cell cycle analysis, in vitro mitochondrial membrane potential assessment, and pharmacokinetics. Int. J. Biol. Macromol. 2019 137 20 31 10.1016/j.ijbiomac.2019.06.188 31252010
    [Google Scholar]
  86. Dalwadi S. Thakkar V.T. Rana H.B. Hybrid liquisolid technique: A novel approach to enhance the in-vitro performance of antidiabetic drugs. Curr. Drug Ther. 2021 16 5 409 422 10.2174/1574885516666210531130134
    [Google Scholar]
  87. Sundaresan A. Niveditha R. Padmanabhan S. Hari B.V. Ramyadevi D. Oro-dissolving systems of papaya extract – liquisolid compacts and lozenges. Int. J. PharmTech Res. 2014 6 7 2083 2091
    [Google Scholar]
  88. Jaipakdee N. Limpongsa E. Sripanidkulchai B. Piyachaturawat P. Preparation of Curcuma comosa tablets using liquisolid techniques: In vitro and in vivo evaluation. Int. J. Pharm. 2018 553 1-2 157 168 10.1016/j.ijpharm.2018.10.031 30316793
    [Google Scholar]
  89. Noppharat K. Jaipakdee N. Limpongsa E. Development of herbal capsules containing mulberry leaf and black tea extracts using the modified liquisolid techniques. Inter. J. Appl. Pharma. 2019 11 4 25 31 10.22159/ijap.2019v11i4.32678
    [Google Scholar]
  90. Parmar K. Patel J. Sheth N. Fabrication and characterization of liquisolid compacts of Embelin for dissolution enhancement. J. Pharm. Investig. 2014 44 5 391 398 10.1007/s40005‑014‑0134‑3
    [Google Scholar]
  91. Parmar K. Patel J. Sheth N. Formulation and development of embelin liquisolid systems using quality by design approach. J. Pharm. Investig. 2016 46 6 547 556 10.1007/s40005‑016‑0239‑y
    [Google Scholar]
  92. Chettupalli AK Amara RR Amarachinta PR Manda RM Garige BS Yata VK Formulation and evaluation of poly herbal liqui-solid compact for its anti-inflammatory effect. Biointerf. Res. Appl. Chem. 2021 12 3 3883 3899 10.33263/BRIAC123.38833899
    [Google Scholar]
  93. Sirithunyalug B. Saenjum C. Charumanee S. Sivamaruthi B.S. Chaiyasut C. Sirithunyalug J. Tipduangta P. Development of colorectal-targeted dietary supplement tablets containing natural purple rice bran oil as a colorectal chemopreventive. Nutrients 2018 10 4 444 10.3390/nu10040444 29617306
    [Google Scholar]
  94. Sheta N.M. Elfeky Y.A. Boshra S.A. Cardioprotective efficacy of silymarin liquisolid in isoproterenol prompted myocardial infarction in rats. AAPS PharmSciTech 2020 21 3 81 10.1208/s12249‑019‑1609‑3 31974855
    [Google Scholar]
  95. Tsai Z. Carver K.A. Gong H.H. Kosai K. Deng J.C. Worley M.J. Detailed mechanisms underlying neutrophil bactericidal activity against streptococcus pneumoniae. Biomedicines 2023 11 8 2252 10.3390/biomedicines11082252 37626748
    [Google Scholar]
  96. Kostelanská K. Kurhajec S. Pavloková S. Vetchý D. Gajdziok J. Franc A. Technology of processing plant extracts using an aluminometasilicate porous carrier into a solid dosage form. Pharmaceutics 2022 14 2 248 10.3390/pharmaceutics14020248 35213981
    [Google Scholar]
  97. Tripathi D. Srivastava M. Rathour K. Rai A.K. Wal P. Sahoo J. Tiwari R.K. Pandey P. A promising approach of dermal targeting of antipsoriatic drugs via engineered nanocarriers drug delivery systems for tackling psoriasis. Drug Metab. Bioanal. Lett. 2023 16 2 89 104 10.2174/2949681016666230803150329 37534794
    [Google Scholar]
  98. Bang J.S. Oh D.H. Choi H.M. Sur B.J. Lim S.J. Kim J.Y. Yang H.I. Yoo M.C. Hahm D.H. Kim K.S. Anti-inflammatory and antiarthritic effects of piperine in human interleukin 1β-stimulated fibroblast-like synoviocytes and in rat arthritis models. Arthritis Res. Ther. 2009 11 2 R49 10.1186/ar2662 19327174
    [Google Scholar]
  99. Chella N Narra N Rama Rao T. Preparation and characterization of liquisolid compacts for improved dissolution of telmisartan. J. Drug Deliv. 2014 2014 692793 10.1155/2014/692793
    [Google Scholar]
  100. Kurhajec S. Kostelanská K. Pavloková S. Vetchý D. Wolaschka T. Gajdziok J. Franc A. Stabilized antioxidative plant extracts formulated by liquisolid technique. J. Drug Deliv. Sci. Technol. 2020 60 102022 10.1016/j.jddst.2020.102022
    [Google Scholar]
  101. Kasturi M. Development of liquisolid compacts: An approach for dissolution enhancement of poorly aqueous soluble drugs. Drug Formulation Design. London, UK IntechOpen 2022 1 8
    [Google Scholar]
  102. Tripathi D. Rathour K. Pandey P. Tiwari R.K. Rai A.K. Basil seed mucilage as a bioadhesive polymer: Development of naproxen sodium microspheres and suppositories with in-vitro and ex-vivo studies. ADMET DMPK 2024 12 6 881 901 10.5599/admet.2372 39713257
    [Google Scholar]
  103. Mahmood T. Sarfraz R.M. Ismail A. Ali M. Khan A.R. Pharmaceutical methods for enhancing the dissolution of poorly water-soluble drugs. Assay Drug Dev. Technol. 2023 21 2 65 79 10.1089/adt.2022.119 36917562
    [Google Scholar]
  104. Khazim M.E. Hasan H.J. Hanoon N.M. Al-Saidy H.A. Improvement of the photostability of nimodipine by using liquisolid compacts technique. Univer. Thi-Qar J. Sci. 2021 8 2 43 51 10.32792/utq/utjsci.v8i2.811
    [Google Scholar]
/content/journals/loc/10.2174/0115701786365794250717080612
Loading
Next-Generation Plant Constituents Delivery by Harnessing Liquisolid Technology for Optimal Pharmaceutical Outcomes: A Review
Bentham Science Publishers ; https://doi.org/10.2174/0115701786365794250717080612
/content/journals/loc/10.2174/0115701786365794250717080612
/content/journals/loc/10.2174/0115701786365794250717080612
Loading

Data & Media loading...


  • Article Type:     Review Article
Keywords: therapeutic outcomes ; poor solubility ; phytoconstituents ; powder compact ; drug delivery and applications ; Liquisolid technique

Most Cited Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test