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2000
Volume 22, Issue 12
  • ISSN: 1570-1786
  • E-ISSN: 1875-6255

Abstract

The effectiveness of herbal preparations depends on achieving therapeutic plasma concentrations. The efficacy of phytoconstituents is often hindered by poor lipid solubility, high molecular weight, or degradation in the gastric environment. The liquisolid system is a promising technique for developing herbal pharmaceuticals due to its simple manufacturing process, low production costs, industrial viability, excellent flow and compaction properties, and ability to protect active ingredients from oxidation. The liquisolid technique converts liquid formulations, suspensions, or solutions into dry, free-flowing, and compressible powder blends. This approach enhances drug dissolution rates, maintains the photostability of phytoconstituents, and protects against humidity, thereby extending shelf-life. However, the technique faces challenges, such as carefully selecting excipients and difficulties with high-dose formulations. Overcoming these challenges is crucial to improving the therapeutic efficacy of phytoconstituents in pharmaceutical applications. This review explores the liquisolid technique for phytoconstituent drug delivery by conducting an extensive literature analysis using PubMed, CrossRef, and Google Scholar databases. Advances in excipient selection and formulation strategies can significantly enhance the therapeutic potential of herbal treatments employing liquisolid technology, fostering the development of advanced drug delivery systems in modern pharmaceuticals.

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2026-01-04

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Next-Generation Plant Constituents Delivery by Harnessing Liquisolid Technology for Optimal Pharmaceutical Outcomes: A Review
Lett. Org. Chem. 22, 913 (2025); https://doi.org/10.2174/0115701786365794250717080612
/content/journals/loc/10.2174/0115701786365794250717080612
/content/journals/loc/10.2174/0115701786365794250717080612
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  • Article Type:     Review Article
Keyword(s): drug delivery and applications; Liquisolid technique; phytoconstituents; poor solubility; powder compact; therapeutic outcomes

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