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2000
Volume 22, Issue 10
  • ISSN: 1570-1786
  • E-ISSN: 1875-6255

Abstract

A new series of pyridine-fused pyranoquinoline derivatives have been synthesized one-pot three-component coupling of hydroxyquinoline, aromatic aldehydes, and 2-aminopropene-1,1,3-tricarbonitrile in the presence of 10 mol% of triethylamine at 80°C in ethanol under reflux conditions. It is an effective synthetic method due to its simple operating procedure, wide range of substrates, column chromatography-free separations, and high product yield.

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2025-04-04
2025-10-25

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One-pot Three-component Synthesis of New Pyridine-fused Pyranoquinoline Derivatives
Lett. Org. Chem. 22, 810 (2025); https://doi.org/10.2174/0115701786374956250312062948
/content/journals/loc/10.2174/0115701786374956250312062948
/content/journals/loc/10.2174/0115701786374956250312062948
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Supplements

A supplementary information file containing 1H and 13C NMR data of compounds 9a-k is available on the journal website.

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  • Article Type:     Research Article
Keyword(s): 2-aminopropene-1,1,3-tricarbonitrile; 4-hydroxy-1-methylquinolin-2(1H)-one; aromatic aldehydes; column free chromatographic separation; multicomponent reaction; pyranoquinolines; three-component reaction

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