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2000
Volume 22, Issue 8
  • ISSN: 1570-1786
  • E-ISSN: 1875-6255

Abstract

A palladium-catalyzed Heck cyclization/reductive aminocarbonylation was developed for alkene-tethered carbamoyl chlorides with nitroarenes using Mo(CO) as a convenient CO surrogate and reductant. This process constructed one C–N bond and two C–C bonds, yielding a variety of amidated oxindoles/γ-lactams with an all-carbon quaternary stereocenter under gas-free conditions. The transformation exhibited a wide range of substrate compatibility and exceptional functional group tolerance.

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2025-02-11
2025-09-03

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Palladium-Catalyzed Heck Cyclization/Reductive Aminocarbonylation of Carbamoyl Chlorides with Nitroarenes
Lett. Org. Chem. 22, 661 (2025); https://doi.org/10.2174/0115701786367852250207102915
/content/journals/loc/10.2174/0115701786367852250207102915
/content/journals/loc/10.2174/0115701786367852250207102915
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  • Article Type:     Research Article
Keyword(s): carbamoyl chlorides; Heck cyclization; Mo(CO)6; nitroarenes; Palladium; reductive aminocarbonylation

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