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2000
Volume 22, Issue 8
  • ISSN: 1570-1786
  • E-ISSN: 1875-6255

Abstract

A novel class of eighteen 2-((9-carbazol-9-yl)methyl)-5-(benzylthio)-1,3,4-oxadiazole derivatives were designed, synthesized and screened for their antibacterial activities against pv. (), pv. () and pv. (). Preliminary bioactivity test results indicated that some compounds showed moderate to good inhibitory effects against the tested bacteria at the concentrations of 100 g/mL and 50 g/mL. Among them, compounds 2-((9-carbazol-9-yl)methyl)-5-((2,6-dichloro benzyl)thio)-1,3,4-oxadiazole () and 2-((9-carbazol-9-yl)methyl)-5-((4-(trifluoromethyl)benzyl)thio)-1,3,4-oxadiazole () exhibited the best inhibitory effects against , and than other compounds, which displayed a wide range of antibacterial activities. Further bioactive applications of these molecules are in progress in our laboratories.

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2025-02-07
2025-09-03

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Design, Synthesis, and Antibacterial Activity of Carbazole Derivatives Containing 1,3,4-Oxadiazole Thioether Moiety
Lett. Org. Chem. 22, 653 (2025); https://doi.org/10.2174/0115701786364488250106032137
/content/journals/loc/10.2174/0115701786364488250106032137
/content/journals/loc/10.2174/0115701786364488250106032137
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  • Article Type:     Research Article
Keyword(s): 1,3,4-oxadiazole; antibacterial activity; Carbazole; plant bacterial disease; Pseudomonas syringae pv. Actinidiae; thioether; Xanthomonas axonopodis pv. Citri; Xanthomonas oryzae pv. Oryzae

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