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2000
Volume 22, Issue 6
  • ISSN: 1570-1786
  • E-ISSN: 1875-6255

Abstract

This research project focuses on the synthesis and characterization of a novel azo ligand, 4-CMBP, derived from 2-amino-6-methylbenzothiazole, and its complexes with Co(III) and Ni(II) ions. The study aims to investigate the structural and biological properties of the ligand and its complexes, with a particular emphasis on their potential applications in environmental and health sectors. The ligand and its complexes were characterized using techniques such as melting point measurements, nuclear magnetic resonance, mass spectrometry, Fourier-transform infrared spectroscopy, UV-Vis spectroscopy, elemental analysis, atomic absorption spectroscopy, molar conductivity, and magnetic susceptibility measurements. Biological activities were evaluated through the removal percentages of Co(III) and Ni(II) from eleven popular brands of lipsticks in the Iraqi market, antimicrobial screening against bacteria and fungi, ADMET predictions, and anticancer activity tests in human liver cancer cell lines. Characterization confirmed the successful synthesis of the ligand and the formation of octahedral complexes with Co(III) and Ni(II) ions. The analysis revealed nickel concentrations ranging from 0.36 to 3.08 ppm, with varying safety implications. Antimicrobial screening showed promising activity, and predictions indicated favorable oral bioavailability. The ligand and its complexes exhibited significant anticancer activity against liver cancer cell lines. The study successfully synthesized and characterized the azo ligand 4-CMBP and its metal complexes, highlighting their intriguing geometries and promising biological activities, with potential applications in environmental remediation, antimicrobial agents, and anticancer therapeutics.

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Synthesis, Characterization, and Toxicity Studies of Azo Dye Ligand for Metal Assessment in Different Brands of Lipsticks in Iraq
Lett. Org. Chem. 22, 475 (2025); https://doi.org/10.2174/0115701786333849241119110649
/content/journals/loc/10.2174/0115701786333849241119110649
/content/journals/loc/10.2174/0115701786333849241119110649
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  • Article Type:     Research Article
Keyword(s): ADMET; azo; benzothiazole; lipsticks; LOQ; metal complexes

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