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2000
Volume 22, Issue 5
  • ISSN: 1570-1786
  • E-ISSN: 1875-6255

Abstract

We present a protocol for the synthesis of 3-aminopyrazoles through an eco-friendly cyclocondensation reaction of -oxo ketene-acetals with hydrazine hydrates. The reaction runs by using HO as a solvent to give access to a library of 3-aminopyrazole derivatives (25 examples) under mild and operationally simple conditions. In this study, the green synthesis method showed various fascinating advantages, such as good scale-up performance, good Eco-scale value (89 points), and reusable aqueous medium. 3-aminopyrazoles were further confirmed by X-ray crystallographic analysis, and a reasonable reaction mechanism was proposed.

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2025-01-02
2025-09-08

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Eco-friendly and Practical Synthesis of 3-Aminopyrazoles in Water
Lett. Org. Chem. 22, 379 (2025); https://doi.org/10.2174/0115701786333282241114104241
/content/journals/loc/10.2174/0115701786333282241114104241
/content/journals/loc/10.2174/0115701786333282241114104241
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  • Article Type:     Research Article
Keyword(s): 3-aminopyrazoles; 4-dodecylbenzene sulfonic acid; Ketene-N; phenyl ring; pyrazole derivatives; S-acetals

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