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2000
Volume 22, Issue 4
  • ISSN: 1570-1786
  • E-ISSN: 1875-6255

Abstract

A rapid and direct route for the new synthesis of various quinazolines-4 (1)-ones with appropriate yields through a three-component reaction consisting of the amine-trichloroacetonitrile adduct and isatoic anhydride is a remarkable achievement in organic chemistry. The use of CuO as the catalyst in DMF under reflux conditions at 110°C for 4 hours offers reaction conditions, which are conducive to the formation of the desired products while maintaining good selectivity. The simplicity of the one-pot synthesis and using the available raw materials contribute to the ease of purification of the synthesized quinazolines-4 (1)-ones, streamlining the overall synthetic process. The synthesized product is often found in drugs and other bioactive molecules.

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2025-09-08

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Copper-Catalyzed Synthesis of Quinazolin-4(1H)-one from Amine-Trichloroacetonitrile Adduct and Isatoic Anhydride
Lett. Org. Chem. 22, 308 (2025); https://doi.org/10.2174/0115701786319625240912112357
/content/journals/loc/10.2174/0115701786319625240912112357
/content/journals/loc/10.2174/0115701786319625240912112357
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  • Article Type:     Research Article
Keyword(s): amine; copper-catalyzed; isatoic anhydride; one-pot; Quinazoline-4(1H)-one; three-component reaction; trichloroacetonitrile

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