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2000
Volume 22, Issue 4
  • ISSN: 1570-1786
  • E-ISSN: 1875-6255

Abstract

A general and efficient multi-component reaction has been established for the construction of 5-amino tetrazoles and guanidines under mild reaction conditions. All the substrates are readily carried out under optimized reaction conditions to provide their respective target products in good to excellent yields. The regioselectivity of the reaction is also explained in this manuscript. Further, this method is free, uses water as a green solvent, and is practical (at room temperature and under an open atmosphere). In addition, we could not identify any other products during the reaction procedure. Phenyltetrazoleamines are readily converted into their cross-coupled products in good to high yield under mild reaction conditions.

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Iodine Promoted Desulfurization of Isothiocyanate in Water: Synthesis of 5-Amino-1-Aryl/Alkyl Tetrazoles, Aryl/Alkyl Guanidines and their Conversion
Lett. Org. Chem. 22, 292 (2025); https://doi.org/10.2174/0115701786315427240826091802
/content/journals/loc/10.2174/0115701786315427240826091802
/content/journals/loc/10.2174/0115701786315427240826091802
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  • Article Type:     Research Article
Keyword(s): 5-amino aryl/alky tetrazoles; aryl/alkyl guanidine’s; C-N cross-coupling reaction; desulphurization; green reaction; metal free reaction

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