Antibacterial Activity and Structure-activity Relationship Studies of 4- substituted-5-(diphenylmethyl)-2,4-dihydro-3H-1,2,4-triazole-3-thiones

Seventeen 4-substituted-5-(diphenylmethyl)-2,4-dihydro-3H-1,2,4-triazole-3-thiones were synthesized and the structures of the compounds were determined by 1H NMR and IR spectra. In vitro antibacterial potency of all title compounds was evaluated. Additionally, the initial in vitro toxicity screening was performed for one compound using the MTT assay technique. A structure-activity relationship (SAR) studies have been carried out to determine the relevance of the different parameters that define the potency of title s-triazoles.