Synthesis and Antibacterial Activity of Oxime Ester Derivatives from Dehydroabietic Acid

A series of oxime ester derivatives containing dehydroabietyl group were synthesized from dehydroabietic acid. Their structures were characterized by IR, 1HNMR, MS, and elemental analysis. The preliminary antibacterial activity results indicate that these compounds display extensive anti-bacterial activity against Escherichia coli, Staphyloccocus aureu, Klebsiella pneumoniae, Pseudomonas aeruginosa, Escherichia aerogenes and Staphyloccocus epidermidis. Compounds (5a, 5b, 5c, 5d, 5e, 5f) exhibit excellent anti-bacterial activity against Escherichia coli with the diameter of inhibition zone is 10.91mm, 11.03mm, 12.92mm, 13.48mm , 11.59mm and 11.58mm respectively,compared with the diameter of inhibition zone of 9.66mm of the commercial compound bromogeramine. Furthermore, Compounds(5d) exhibited the same level of antibacterial activity against Staphyloccocus epidermidis when compared with bromogeramine and Ampicillin Na.