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2000
Volume 2, Issue 6
  • ISSN: 1570-1808
  • E-ISSN: 1875-628X

Abstract

We reported that the extract of Mulgedium tatarica DC. exhibits anticancer activity. With the help of a tumor cell killing bioassay, the sesquiterpene lactones lactucopicrin (1), 11,13β-dihydrolactucopicrin (2), lactucin (3) and 11,13β-dihydrolactucin (4) were isolated and identified from this medicinal herb. SAR studies indicate that the ester group at position 8 and the exocyclic methylene group at position 11 play a major role in anticancer activities of lactucin-like guaianolides, a kind of sesquiterpene lactone.

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/content/journals/lddd/10.2174/1570180054771581
2005-09-01
2024-11-07
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