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2000
Volume 2, Issue 6
  • ISSN: 1570-1808
  • E-ISSN: 1875-628X

Abstract

5,6-Dihydroxypyrimidine-4-carboxylic acids are a promising series of hepatitis C virus (HCV) NS5B polymerase inhibitors that bind at the active site of the enzyme. Here we report the evolution and SAR of a series of 2-{2-[(arylsulfonyl)amino]phenyl analogues that show greater than 2 orders of magnitude improved activity over the original lead.

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/content/journals/lddd/10.2174/1570180054771527
2005-09-01
2024-11-12
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/content/journals/lddd/10.2174/1570180054771527
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  • Article Type:
    Research Article
Keyword(s): HCV; inhibitors; NS5B Polymerase; phenyldihydroxypyrimidines; sulfonamides
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